Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4983095 | 0.79 | PDE4B (0.42) | PDE4BDRD3 | |
| SCHEMBL20537443 | 0.71 | LRRK2 (0.47) | — | |
| SCHEMBL20537315 | 0.70 | LRRK2 (0.48) | — | |
| SCHEMBL15347806 | 0.70 | GSK3B (0.45) | PDE4B | |
| SCHEMBL20537246 | 0.70 | LRRK2 (0.49) | — | |
| SCHEMBL20537247 | 0.69 | LRRK2 (0.54) | — | |
| SCHEMBL20537296 | 0.69 | LRRK2 (0.58) | — | |
| SCHEMBL6584261 | 0.69 | PDE4B (0.51) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL20537313 | 0.69 | LRRK2 (0.55) | — | |
| SCHEMBL11427405 | 0.68 | PDE4A (0.64) | PDE4BPDE4APDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017919-A | Compounds and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0887340-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco Inc. (JP) | 1998-12-30 | — | — | EP | disclosed |