Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 14/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.64 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | LDHA | P00338 | 1/20 | 0.59 |
| ▸ | STAT1 | P42224 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175580 | 0.83 | DYRK1A (1.00) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL10170616 | 0.83 | DYRK1A (1.00) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL4501407 | 0.82 | DYRK1A (0.71) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL30561486 | 0.82 | DYRK1A (0.79) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL715950 | 0.82 | DYRK1A (1.00) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL19807983 | 0.82 | DYRK1A (0.79) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL11279344 | 0.82 | DYRK1A (1.00) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL15521825 | 0.82 | DYRK1A (1.00) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL758050 | 0.82 | CLK1 (0.78) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL6058154 | 0.81 | DYRK1A (0.77) | DYRK1ANPC1RAB9ACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183232-B1 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2009017822-A2 | PI3 KINASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2009-02-05 | — | — | WO | disclosed |