Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451912 | 0.90 | GAA (0.50) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL2978814 | 0.84 | GLA (0.52) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL2978810 | 0.84 | GLA (0.52) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL15710678 | 0.83 | L3MBTL1 (0.48) | SMN1; SMN2ALDH1A1LMNAHSP90AA1TSHR | |
| SCHEMBL23074882 | 0.81 | KDM4E (0.52) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL14854718 | 0.81 | KDM4E (0.52) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL15710532 | 0.81 | L3MBTL1 (0.52) | SMN1; SMN2ALDH1A1LMNAHSP90AA1TSHR | |
| SCHEMBL4332122 | 0.81 | KDM4E (0.52) | KDM4EGLAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL15710724 | 0.80 | SIGMAR1 (0.45) | SMN1; SMN2ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL15710416 | 0.79 | POLB (0.36) | KDM4EGAASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160257686-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2016-09-08 | — | — | US | disclosed |
| US-20140142099-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | PRINCIPIA BIOPHARMA INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-8487018-B2 | Heavy metal-free and anaerobically compostable vinyl halide compositions, articles and landfill biodegradation | BIOTECH PRODUCTS, LLC (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110159766-A1 | HEAVY METAL-FREE AND ANAEROBICALLY COMPOSTABLE VINYL HALIDE COMPOSITIONS, ARTICLES AND LANDFILL BIODEGRADATION | BIOTECH PRODUCTS, LLC (US) | 2011-06-30 | — | — | US | disclosed |
| US-7956101-B2 | Anaerobically compostable polymeric compositions, articles and landfill biodegradation | BIOTECH PRODUCTS, LLC (US) | 2011-06-07 | — | — | US | disclosed |
| US-7939582-B2 | Rendered compostable by prodegradant system of organotitanate or zirconate and organotin | BIOTECH PRODUCTS, LLC (US) | 2011-05-10 | — | — | US | disclosed |
| US-7902271-B2 | Compostable vinyl halide polymer compositions, composites and landfill biodegradation | BIOTECH PRODUCTS, LLC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20090275111-A1 | Anaerobically Compostable Polymeric Compositions, Articles and Landfill Biodegradation | BIOTECH PRODUCTS, LLC (US) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142099-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | BMX, BLK, ITK | KDM4E 2028/4885GLA 4503/4885GAA 2623/4885 |
| US-20160257686-A1 | Purinone Derivatives as Tyrosine Kinase Inhibitors | BMX, BLK, ITK | KDM4E 2028/4885GLA 4503/4885GAA 2623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.