SCHEMBL8086470

SCHEMBL8086470

c1cnc(C2CCc3ccccc32)nc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1A P35348 3/20 0.63
ADRA2A P08913 3/20 0.51
ADRA1D P25100 1/20 0.51
ADRA1B P35368 1/20 0.51
CYP2D6 P10635 2/20 0.44
HTR1A P08908 1/20 0.44
OPRM1 P35372 1/20 0.44
CYP11B2 P19099 4/20 0.44
CYP19A1 P11511 4/20 0.44
CYP17A1 P05093 1/20 0.44
IDO1 P14902 2/20 0.43
PDPK1 O15530 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
BLM P54132 1/20 0.43
KMT2A Q03164 1/20 0.43
TAAR1 Q96RJ0 1/20 0.43
SIGMAR1 Q99720 2/20 0.41
ADRA2B P18089 1/20 0.39
ADRA2C P18825 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9814150 0.89 ADRA1A (0.65) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL3962724 0.89 ADRA1A (0.65) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL3955741 0.89 ADRA1A (0.65) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL10650694 0.83 ADRA1A (0.57) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL28329126 0.79 ADRA1A (0.53) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL31484206 0.78 ADRA1A (1.00) ADRA1AADRA2AADRA1DADRA1B
SCHEMBL966691 0.78 ADRA1A (1.00) ADRA1AADRA2AADRA1DADRA1B
SCHEMBL30268068 0.76 ADRA1A (0.55) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL30268228 0.76 ADRA1A (0.55) ADRA1AADRA2AADRA1DADRA1BCYP2D6
SCHEMBL13726791 0.76 ADRA1A (0.55) ADRA1AADRA2AADRA1DADRA1BCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0677565-B1 Liquid crystal composition, liquid crystal device using the composition, liquid crystal apparatus and display method CANON KK (JP) 2000-10-18 EP disclosed
US-5688437-A Liquid crystal composition, liquid crystal device using the composition, liquid crystal apparatus and display method CANON KABUSHIKI KAISHA (JP) 1997-11-18 US disclosed
EP-0677565-A2 Liquid crystal composition, liquid crystal device using the composition, liquid crystal apparatus and display method CANON KABUSHIKI KAISHA (JP) 1995-10-18 EP disclosed