Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9814150 | 1.00 | ADRA1A (0.65) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL3962724 | 1.00 | ADRA1A (0.65) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL8086470 | 0.89 | ADRA1A (0.63) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL7560459 | 0.86 | ADRA1A (0.57) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL4204524 | 0.85 | ADRA1A (0.59) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL3171152 | 0.84 | ADRA1A (0.59) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL30268068 | 0.83 | ADRA1A (0.55) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL30268228 | 0.83 | ADRA1A (0.55) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL13726791 | 0.83 | ADRA1A (0.55) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 | |
| SCHEMBL769101 | 0.79 | ADRA1A (1.00) | ADRA1AADRA2AADRA1DADRA1BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550473-B2 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20050124640-A1 | Pyrimidine derivatives useful as inhibitors of PKC-theta | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124640-A1 | Pyrimidine derivatives useful as inhibitors of PKC-theta | PRKCQ, PRKCZ, PRKCH | ADRA1A 1128/4885ADRA2A 825/4885ADRA1D 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.