Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.68 |
| ▸ | NPC1 | O15118 | 9/20 | 0.68 |
| ▸ | RAB9A | P51151 | 9/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.68 |
| ▸ | RELA | Q04206 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 11/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318618 | 0.84 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL8085594 | 0.83 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL3426740 | 0.81 | NPC1 (1.00) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL31031084 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL29740239 | 0.78 | NPC1 (0.68) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL7319653 | 0.77 | HRH3 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| Hydrochloric Acid SCHEMBL7307734 | 0.76 | HRH3 (0.65) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL12692485 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL4147815 | 0.76 | NPC1 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 | |
| SCHEMBL1728599 | 0.76 | SMN1; SMN2 (0.66) | SMN1; SMN2NPC1RAB9AMAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103724-A | EXHIBIT MAINLY ANTIPSYCHOTIC EFFECTS, E.G., SCHIZOPHRENIA, ORGANIC MENTAL DISORDERS, AFFECTIVE DISORDERS, ANXIETY, PERSONALITY DISORDERS; NEUROLEPTIC ACTIVITIY; ATYPICAL ANTIPSYCHOTICS, COGNITION ACTIVATORS, ANTIDEPRESSANTS; | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2000-08-15 | — | — | US | disclosed |
| EP-0935599-A1 | 2-METHOXYPHENYLPIPERAZINE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1999-08-18 | — | — | EP | disclosed |
| WO-1998018797-A1 | 2-METHOXYPHENYLPIPERAZINE DERIVATIVES | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1998-05-07 | — | — | WO | disclosed |