Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8078878 | 0.86 | GPR35 (0.41) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Acetoacetic Acid SCHEMBL27440708 | 0.84 | KDM4E (0.32) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27463844 | 0.82 | KDM4E (0.38) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8085969 | 0.77 | NQO2 (0.40) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL8183610 | 0.77 | MEN1 (0.32) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8086079 | 0.75 | LATS1 (0.35) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5973164 | 0.75 | NQO2 (0.41) | ALDH1A1MAPTNQO2 | |
| SCHEMBL27444188 | 0.75 | SLC7A5 (0.40) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8498410 | 0.74 | NQO2 (0.32) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5973831 | 0.74 | NQO2 (0.40) | ALDH1A1MAPTNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080743-A | AS CHEMICAL INTERMEIDATES FOR PREPARING DRUGS | NOVARTIS AG (CH) | 2000-06-27 | — | — | US | disclosed |
| EP-0853617-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | Novartis AG (CH) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997008155-A1 | NOVEL 2,3-DIOXO-1,2,3,4-TETRAHYDRO-QUINOYXALINYL DERIVATIVES | NOVARTIS AG (CH) | 1997-03-06 | — | — | WO | disclosed |