Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363766 | 0.88 | AGTR1 (0.56) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL76 | 0.86 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL459 | 0.85 | AGTR1 (0.52) | AGTR1AGTR2ABCC4ABCB11PDE3A | |
| SCHEMBL9327743 | 0.85 | AGTR1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL186 | 0.85 | AGTR1 (0.65) | AGTR1AGTR2 | |
| SCHEMBL16330299 | 0.84 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL287 | 0.84 | AGTR1 (0.51) | AGTR1AGTR2 | |
| SCHEMBL7366694 | 0.82 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL16327904 | 0.82 | AGTR1 (0.61) | AGTR1AGTR2 | |
| SCHEMBL986792 | 0.82 | AGTR1 (0.62) | AGTR1AGTR2ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000508347-A | — | — | 2000-07-04 | — | — | JP | claimed |
| EP-0966282-A1 | USE OF ANGIOTENSIN II ANTAGONISTS TO TREAT SYMPTOMATIC HEART FAILURE | Merck & Co., Inc. (US) | 1999-12-29 | — | — | EP | claimed |
| WO-1998030216-A1 | USE OF ANGIOTENSIN II ANTAGONISTS TO TREAT SYMPTOMATIC HEART FAILURE | MERCK & CO., INC. (US) | 1998-07-16 | — | — | WO | claimed |