Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 6/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13090541 | 0.88 | LMNA (0.46) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL314537 | 0.86 | ALDH1A1 (0.42) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL10099092 | 0.84 | MAPT (0.59) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL5440649 | 0.83 | LMNA (0.59) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL10099061 | 0.79 | KDM4E (0.41) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4816462 | 0.78 | LMNA (0.53) | LMNAMAPTKDM4EALDH1A1TSHR | |
| SCHEMBL8271690 | 0.76 | MAPT (0.43) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL2838267 | 0.76 | ALDH1A1 (0.39) | MAPTKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL13905092 | 0.75 | LMNA (0.50) | LMNAMAPTKDM4EALDH1A1TSHR | |
| SCHEMBL313189 | 0.74 | CSF1R (0.44) | LMNAMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009014730-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2009-01-29 | — | — | WO | disclosed |