Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499256 | 0.83 | REN (0.44) | RENCYP3A4AOC3EPHX2TSHR | |
| SCHEMBL499694 | 0.81 | REN (0.48) | RENCYP3A4AOC3EPHX2TSHR | |
| SCHEMBL499203 | 0.81 | SLC6A4 (0.52) | RENCYP3A4TSHRMAPK1HTT | |
| SCHEMBL498922 | 0.81 | SLC6A4 (0.52) | RENCYP3A4TSHRMAPK1HTT | |
| SCHEMBL499635 | 0.79 | REN (0.46) | RENCYP3A4AOC3EPHX2TSHR | |
| SCHEMBL498921 | 0.79 | REN (0.39) | RENCYP3A4AOC3TSHRMAPK1 | |
| SCHEMBL499264 | 0.79 | REN (0.39) | RENCYP3A4AOC3TSHRMAPK1 | |
| SCHEMBL13301277 | 0.78 | REN (0.62) | RENCYP3A4 | |
| SCHEMBL10253871 | 0.78 | REN (0.62) | RENCYP3A4 | |
| SCHEMBL4754043 | 0.75 | SLC6A4 (0.40) | RENCYP3A4AOC3TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |