Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13656459 | 1.00 | MAPT (0.55) | MAPTALDH1A1HTTTDP1ENPP2 | |
| SCHEMBL8079721 | 0.86 | MAPT (0.52) | MAPTALDH1A1HTR7KCNH2LMNA | |
| SCHEMBL13656461 | 0.86 | MAPT (0.52) | MAPTALDH1A1HTR7KCNH2LMNA | |
| SCHEMBL15445827 | 0.82 | MAPT (0.66) | MAPTALDH1A1HTTTDP1ENPP2 | |
| SCHEMBL8014422 | 0.74 | MAPT (0.71) | MAPTHTR7KCNH2LMNASMN1; SMN2 | |
| SCHEMBL18587973 | 0.73 | PTGS2 (0.44) | MAPTALDH1A1LMNAKMT2AACHE | |
| SCHEMBL15347670 | 0.68 | POLB (0.73) | MAPTALDH1A1TDP1LMNASMN1; SMN2 | |
| SCHEMBL5741339 | 0.68 | SIRT6 (0.62) | MAPTALDH1A1HTTTDP1LMNA | |
| SCHEMBL3637451 | 0.67 | KCNH2 (0.63) | MAPTALDH1A1HTTTDP1HTR7 | |
| SCHEMBL4249336 | 0.67 | KCNH2 (0.63) | MAPTALDH1A1HTTTDP1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |