Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.43 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16542344 | 0.90 | TAAR1 (0.44) | TAAR1SIRT2CTBP2KDM4ENR3C2 | |
| SCHEMBL16542314 | 0.85 | TAAR1 (0.44) | TAAR1SIRT2CTBP2KDM4EALOX5 | |
| SCHEMBL4398478 | 0.85 | KDM4E (0.46) | TAAR1CTBP2KDM4EALOX5HCAR2 | |
| SCHEMBL6928724 | 0.83 | MAOB (0.47) | TAAR1SIRT2CTBP2KDM4EMAOB | |
| SCHEMBL9181973 | 0.80 | TAAR1 (0.58) | TAAR1SIRT2KDM4EALOX5HCAR2 | |
| SCHEMBL16244375 | 0.79 | LMNA (0.50) | TAAR1SIRT2CTBP2KDM4ENR3C2 | |
| SCHEMBL3053811 | 0.77 | TAAR1 (0.55) | TAAR1CTBP2KDM4ENR3C2HPGD | |
| SCHEMBL30341383 | 0.77 | TAAR1 (0.55) | TAAR1CTBP2KDM4ENR3C2HPGD | |
| SCHEMBL13886131 | 0.75 | PTGER1 (0.43) | TAAR1CTBP2KDM4EHPGDALDH1A1 | |
| SCHEMBL8573889 | 0.75 | TAAR1 (0.53) | TAAR1CTBP2KDM4ENR3C2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080869-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0850232-B1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMA PROD (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-6008365-A | ADRENORECEPTOR AGONISTS AND DOPAMINE DA2-RECEPTOR AGONISTS, USEFUL IN THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5977384-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5973167-A | Intermediates for making benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5846989-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-12-08 | — | — | US | disclosed |
| EP-0850232-A1 | BENZOTHIAZOLONE DERIVATIVES | Astra Pharmaceuticals Limited (GB) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010227-A1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMACEUTICALS LIMITED (GB) | 1997-03-20 | — | — | WO | disclosed |