SCHEMBL8088765

SCHEMBL8088765

CC1=C(n2cc(N)cc(Br)c2=O)c2cc([N+](=O)[O-])ccc2OC1(C)C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.36
TDP1 Q9NUW8 3/20 0.36
ALDH1A1 P00352 2/20 0.36
MEN1 O00255 5/20 0.34
KMT2A Q03164 5/20 0.34
MALT1 Q9UDY8 1/20 0.33
TSHR P16473 1/20 0.33
CHEK1 O14757 1/20 0.32
PIM1 P11309 1/20 0.32
LIMK1 P53667 1/20 0.32
TYRO3 Q06418 1/20 0.32
MAPK14 Q16539 1/20 0.32
CLK4 Q9HAZ1 1/20 0.32
POLB P06746 1/20 0.32
CASP3 P42574 2/20 0.32
CASP1 P29466 1/20 0.32
CASP4 P49662 1/20 0.32
CASP7 P55210 1/20 0.32
CASP9 P55211 1/20 0.32
CASP6 P55212 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8085265 0.91 MEN1 (0.35) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8189795 0.90 MEN1 (0.36) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8077044 0.88 PDE7A (0.34) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8077008 0.86 TDP1 (0.39) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8085054 0.84 ALDH1A1 (0.35) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8090547 0.83 SMN1; SMN2 (0.38) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8084356 0.82 MEN1 (0.35) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8088643 0.82 CYP3A4 (0.36) CYP3A4TDP1ALDH1A1MEN1KMT2A
SCHEMBL8090263 0.82 MALT1 (0.33) MALT1
SCHEMBL8076960 0.81 MEN1 (0.37) CYP3A4TDP1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6153627-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-11-28 US disclosed
US-6040308-A Chroman derivatives MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2000-03-21 US disclosed
US-5387587-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-07 US disclosed
US-5013853-A Chroman derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1991-05-07 US disclosed
EP-0340718-A1 Chroman derivatives MERCK PATENT GmbH (DE) 1989-11-08 EP disclosed