Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 10/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090116 | 0.90 | ABCC9 (0.46) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL8090277 | 0.87 | ABCC9 (0.49) | ABCC9MAPTLMNAKMT2AABCC8 | |
| SCHEMBL10695898 | 0.87 | ABCC9 (0.49) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL8077255 | 0.86 | ABCC9 (0.49) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL8088369 | 0.86 | ABCC9 (0.49) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL8085247 | 0.84 | ABCC9 (0.47) | ABCC9MAPTLMNASMN1; SMN2HTT | |
| SCHEMBL9143643 | 0.82 | ABCC9 (0.48) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL7269364 | 0.82 | ABCC9 (0.48) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL9143634 | 0.82 | ABCC9 (0.48) | ABCC9LMNAABCC8KCNJ11KCNJ8 | |
| SCHEMBL7274118 | 0.82 | ABCC9 (0.58) | ABCC9LMNAABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |