Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22545922 | 0.94 | TGM2 (0.45) | KMT2ATGM2MAPTTSHRSMN1; SMN2 | |
| SCHEMBL11501378 | 0.94 | TGM2 (0.45) | KMT2ATGM2MAPTTSHRSMN1; SMN2 | |
| SCHEMBL7750555 | 0.91 | — | — | |
| SCHEMBL2187966 | 0.82 | KMT2A (0.48) | KMT2AMAPTTSHRSMN1; SMN2MEN1 | |
| SCHEMBL8448473 | 0.82 | KMT2A (0.40) | KMT2AMAPTTSHRSMN1; SMN2RAB9A | |
| SCHEMBL7456594 | 0.82 | MAPT (0.64) | KMT2AMAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL1783979 | 0.82 | KMT2A (0.44) | KMT2AMAPTTSHRSMN1; SMN2KDM4E | |
| SCHEMBL7536185 | 0.81 | KMT2A (0.42) | KMT2AMAPTTSHRSMN1; SMN2RAB9A | |
| SCHEMBL27733678 | 0.75 | KMT2A (0.43) | KMT2ATGM2SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL2993373 | 0.75 | KMT2A (0.44) | KMT2AMAPTTSHRSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049672-A1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2000-11-08 | — | — | EP | claimed |
| WO-1999037612-A1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR TREATING CNS DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 1999-07-29 | — | — | WO | claimed |