Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25130784 | 0.81 | KMT2A (0.44) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL7750555 | 0.78 | — | — | |
| SCHEMBL10575871 | 0.77 | KMT2A (0.45) | KMT2ANPC1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL10569417 | 0.77 | KMT2A (0.45) | KMT2ANPC1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL10355374 | 0.77 | KMT2A (0.45) | KMT2ANPC1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL8088906 | 0.75 | KMT2A (0.44) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL22545922 | 0.73 | TGM2 (0.45) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL11501378 | 0.73 | TGM2 (0.45) | KMT2AMEN1RAB9ANPC1MAPT | |
| SCHEMBL1711267 | 0.72 | CHRNB2 (0.50) | KMT2AMEN1RAB9ANPC1ALDH1A1 | |
| SCHEMBL6779937 | 0.71 | RAB9A (0.45) | KMT2AMEN1RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190099436-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2019-04-04 | — | — | US | disclosed |
| US-20170087172-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. | 2017-03-30 | — | — | US | disclosed |
| US-9365602-B2 | Sodium glucose co-transporter inhibitors and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20140135277-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2014-05-15 | — | — | US | disclosed |
| US-8476413-B2 | Sulfanyl-tetrahydropyran-based compounds and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2013-07-02 | — | — | US | disclosed |
| US-20100311673-A1 | SULFANYL-TETRAHYDROPYRAN-BASED COMPOUNDS AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2010-12-09 | — | — | US | disclosed |
| US-7846945-B2 | Piperdine-based inhibitors of sodium glucose co-transporter 2 and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2010-12-07 | — | — | US | disclosed |
| US-7781577-B2 | 2-[4-Chloro-3-(4-hydroxy-benzyl)-phenyl]-6-methoxy-tetrahydro-pyran-3,4,5-triol; 2-[4-Chloro-3-(4-ethoxy-benzyl)-phenyl]-3,4,5-trihydroxy-piperidine-1-carboxylic acid methyl ester; (2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxytetrahydro-2H-thiopyran-3,4,5-triol; antidibetic, antiobesity agents | LEXICON PHARMACEUTICALS, INC. (US) | 2010-08-24 | — | — | US | disclosed |
| US-20080221164-A1 | Inhibitors of Sodium Glucose Co-Transporter 2 and Methods of Their Use | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2008-09-11 | — | — | US | disclosed |
| US-20080113922-A1 | INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113922-A1 | INHIBITORS OF SODIUM GLUCOSE CO-TRANSPORTER 2 AND METHODS OF THEIR USE | SLC2A1, SLC2A2, SLC5A2 | KMT2A 4234/4885MEN1 4606/4885RAB9A 2405/4885 |
| US-20170087172-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | SLC2A1, SLC2A4, SLC5A2 | KMT2A 4366/4885MEN1 4465/4885RAB9A 2029/4885 |
| US-20190099436-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | SLC2A1, SLC2A4, SLC5A2 | KMT2A 4366/4885MEN1 4465/4885RAB9A 2029/4885 |
| US-20100311673-A1 | SULFANYL-TETRAHYDROPYRAN-BASED COMPOUNDS AND METHODS OF THEIR USE | GPR119, FABP4, LIPC | KMT2A 4144/4885MEN1 4167/4885RAB9A 1961/4885 |
| US-20140135277-A1 | SODIUM GLUCOSE CO-TRANSPORTER INHIBITORS AND METHODS OF THEIR USE | SLC2A1, SLC2A4, SLC5A2 | KMT2A 4366/4885MEN1 4465/4885RAB9A 2029/4885 |
| US-20080221164-A1 | Inhibitors of Sodium Glucose Co-Transporter 2 and Methods of Their Use | SLC2A1, SLC2A2, SLC5A2 | KMT2A 4234/4885MEN1 4606/4885RAB9A 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.