Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8088924 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BCNR1CNR2GLA | |
| SCHEMBL8088456 | 0.93 | MTNR1A (0.49) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8088455 | 0.93 | MTNR1A (0.49) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8104382 | 0.92 | MTNR1A (0.58) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8098444 | 0.89 | MTNR1A (0.60) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8098442 | 0.89 | MTNR1A (0.60) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8088925 | 0.88 | HTR2A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8089150 | 0.88 | HTR2A (0.55) | MTNR1AMTNR1B | |
| SCHEMBL8104745 | 0.88 | MTNR1A (0.59) | MTNR1AMTNR1BCNR1CNR2 | |
| SCHEMBL8088386 | 0.88 | MTNR1A (0.59) | MTNR1AMTNR1BCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | claimed |
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |