Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.39 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.35 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.32 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995153 | 0.79 | SLC9A1 (0.49) | SLC9A1SLC9A2ERCC1ERCC4TSHR | |
| SCHEMBL3973208 | 0.70 | SLC9A1 (0.54) | SLC9A1SLC9A2 | |
| SCHEMBL8007941 | 0.66 | SLC9A1 (0.49) | SLC9A1SLC9A2 | |
| SCHEMBL20150118 | 0.65 | SLC9A1 (0.47) | SLC9A1SLC9A2 | |
| SCHEMBL8007038 | 0.63 | SLC9A1 (0.48) | SLC9A1SLC9A2 | |
| SCHEMBL8097928 | 0.62 | SLC9A1 (0.53) | SLC9A1SLC9A2 | |
| Hydrochloric Acid SCHEMBL8004966 | 0.62 | SLC9A1 (0.47) | SLC9A1SLC9A2 | |
| SCHEMBL8097379 | 0.61 | SLC9A1 (0.50) | SLC9A1SLC9A2 | |
| SCHEMBL27524440 | 0.61 | SLC9A1 (0.40) | SLC9A1SLC9A2 | |
| Cariporide SCHEMBL221094 | 0.60 | SLC9A1 (0.63) | SLC9A1SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748795-B1 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AG (DE) | 2000-08-23 | — | — | EP | claimed |
| EP-0748795-A2 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | claimed |
| EP-0748795-B1 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AG (DE) | 2000-08-23 | — | — | EP | disclosed |
| EP-0748795-A2 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |