Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 3/20 | 0.49 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.49 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20150118 | 0.84 | SLC9A1 (0.47) | SLC9A1SLC9A2CA2L3MBTL1 | |
| SCHEMBL1495564 | 0.77 | CMA1 (0.41) | CMA1PTGS2CA2CA12CA1 | |
| SCHEMBL15459973 | 0.75 | GABRA1 (0.45) | PTGS2GABRA1GABRG2GABRB3CA2 | |
| SCHEMBL1017319 | 0.75 | CYP4F2 (0.47) | CMA1PTGS2CA2CA12CA1 | |
| SCHEMBL2910230 | 0.75 | CA2 (0.41) | CMA1PTGS2CA2CA12CA1 | |
| SCHEMBL1013610 | 0.75 | GSTO1 (0.44) | CMA1PTGS2CA2CA12CA1 | |
| SCHEMBL31726411 | 0.75 | CA2 (0.46) | GABRA1GABRG2GABRB3CA2CA12 | |
| SCHEMBL11962360 | 0.74 | SLC9A1 (0.50) | SLC9A1SLC9A2L3MBTL1 | |
| SCHEMBL11951611 | 0.74 | SLC9A1 (0.50) | SLC9A1SLC9A2L3MBTL1FABP3FABP4 | |
| SCHEMBL8007047 | 0.73 | SLC9A1 (0.60) | SLC9A1SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1062555-C | Substituted benzyloxy carbonyl guanidine, its prepn. method, and application of the same as medicament and medicament containing the same | HOECHST AG (DE) | 2001-02-28 | — | — | CN | disclosed |
| EP-0748795-B1 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AG (DE) | 2000-08-23 | — | — | EP | disclosed |
| US-6022899-A | EFFECTIVE INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-02-08 | — | — | US | disclosed |
| US-5753710-A | INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |
| CN-1145360-A | Substituted benzyloxy carbonyl guanidine, its prepn. method, and application of the same as medicament and medicament containing the same | HOECHST AG (DE) | 1997-03-19 | — | — | CN | disclosed |
| EP-0748795-A2 | Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-12-18 | — | — | EP | disclosed |