Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.62 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.60 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP2 | P08253 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP12 | P39900 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | MMP16 | P51512 | 1/20 | 0.57 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL975666 | 0.96 | CHRNB2 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL27460658 | 0.94 | HDAC7 (0.67) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL12922045 | 0.89 | HDAC7 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL12922053 | 0.87 | HDAC8 (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL974404 | 0.85 | SLC6A3 (0.63) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL12922063 | 0.85 | HDAC7 (0.71) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL13845096 | 0.85 | HDAC7 (0.66) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL12922050 | 0.85 | HDAC7 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL3026631 | 0.83 | GAA (0.64) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 | |
| SCHEMBL25060939 | 0.83 | HDAC7 (0.73) | CHRNB2CHRNB4CHRNA3CHRNA4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-8673911-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2014-03-18 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2014-02-13 | — | — | US | disclosed |
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2011-01-27 | — | — | US | disclosed |
| WO-2009055917-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-05-07 | — | — | WO | disclosed |
| EP-0379057-B1 | Mesogenic epoxy compounds | DOW CHEMICAL CO (US) | 2000-12-06 | — | — | EP | disclosed |
| US-5736620-A | ENHANCED UNIDIRECTIONAL, MECHANICAL PROPERTIES AT LOWER TEMPERATURE | THE DOW CHEMICAL COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5463091-A | Liquid crystals, polyepoxides | THE DOW CHEMICAL COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| US-5391651-A | Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions | THE DOW CHEMICAL COMPANY (US) | 1995-02-21 | — | — | US | disclosed |
| US-5296570-A | Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions | THE DOW CHEMICAL COMPANY (US) | 1994-03-22 | — | — | US | disclosed |
| US-5292831-A | Enhanced unidirectional, mechanical properties | THE DOW CHEMICAL COMPANY (US) | 1994-03-08 | — | — | US | disclosed |
| US-5270405-A | Mesogenic epoxy compounds | THE DOW CHEMICAL COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5270404-A | Curable compositions of mesogen-containing advanced epoxy resins and curing agents therefor | THE DOW CHEMICAL COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5266660-A | Curable compositions containing mesogenic epoxy compounds and cured products thereof | THE DOW CHEMICAL CO. (US) | 1993-11-30 | — | — | US | disclosed |
| US-5227452-A | Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions | THE DOW CHEMICAL COMPANY (US) | 1993-07-13 | — | — | US | disclosed |
| US-5218062-A | Curable mixtures of mesogenic epoxy resins and mesogenic polyamines and cured compositions | THE DOW CHEMICAL COMPANY (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0473935-A2 | Curable mixture of mesogenic epoxy resins and mesogenic polyamines and cured compositions | THE DOW CHEMICAL COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |
| EP-0379057-A2 | Mesogenic epoxy compounds | THE DOW CHEMICAL COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021771-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | CHRNB2 2327/4885CHRNB4 2355/4885CHRNA3 1459/4885 |
| US-20140045850-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC3 | CHRNB2 2327/4885CHRNB4 2355/4885CHRNA3 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.