Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755988 | 0.92 | REN (0.39) | RENCYP3A4 | |
| SCHEMBL498881 | 0.92 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL499139 | 0.92 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL3335914 | 0.91 | REN (0.45) | RENCYP3A4 | |
| SCHEMBL3335773 | 0.91 | REN (0.45) | RENCYP3A4 | |
| SCHEMBL10253709 | 0.90 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL10254107 | 0.90 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL498863 | 0.83 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL498864 | 0.83 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL498963 | 0.83 | REN (0.44) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156816-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |