Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLI1 | P08151 | 2/20 | 0.40 |
| ▸ | GLI2 | P10070 | 2/20 | 0.40 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KYNU | Q16719 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3646622 | 0.91 | PTGIR (0.41) | GLI1GLI2PTGIRMEN1KMT2A | |
| SCHEMBL8082608 | 0.86 | TACR1 (0.43) | GLI1GLI2OPRK1NLRP3MEN1 | |
| SCHEMBL3645986 | 0.83 | TRPM8 (0.41) | GLI1GLI2 | |
| SCHEMBL3650041 | 0.83 | PTGIR (0.41) | GLI1GLI2PTGIROPRM1OPRD1 | |
| SCHEMBL3645320 | 0.83 | CETP (0.42) | PTGIROPRK1OPRM1OPRD1DRD2 | |
| SCHEMBL3648054 | 0.82 | PTGIR (0.40) | GLI1GLI2PTGIROPRM1OPRD1 | |
| SCHEMBL3641635 | 0.81 | TACR1 (0.42) | MEN1KMT2A | |
| SCHEMBL3645573 | 0.79 | PTGIR (0.43) | PTGIRMEN1KMT2A | |
| SCHEMBL3645744 | 0.78 | OPRK1 (0.43) | OPRK1OPRM1OPRD1DRD2DRD3 | |
| SCHEMBL3645748 | 0.78 | OPRK1 (0.43) | OPRK1OPRM1OPRD1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016087-A1 | MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-05 | — | — | WO | disclosed |