Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087801 | 0.87 | KDM4E (0.40) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8603626 | 0.83 | KDM4E (0.54) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8441926 | 0.81 | TSHR (0.42) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8395936 | 0.80 | KDM4E (0.49) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8084364 | 0.79 | TSHR (0.43) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8605315 | 0.76 | KDM4E (0.51) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8320504 | 0.75 | CYP2C9 (0.37) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL10787092 | 0.75 | KDM4E (0.58) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8087898 | 0.72 | MAPT (0.64) | MAPTALDH1A1MEN1KMT2ACYP2C9 | |
| SCHEMBL10373547 | 0.71 | KDM4E (0.54) | MAPTKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758647-A1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | claimed |
| EP-0758647-B1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 2000-11-02 | — | — | EP | disclosed |
| EP-0758647-A1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | disclosed |