Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602746 | 0.82 | TSHR (0.58) | TSHRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8441182 | 0.81 | NPSR1 (0.44) | TSHRKDM4ENPSR1LMNASLC6A3 | |
| SCHEMBL8395766 | 0.79 | ALDH1A1 (0.48) | TSHRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8089331 | 0.79 | MAPT (0.41) | TSHRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8087898 | 0.78 | MAPT (0.64) | TSHRMAPTMEN1KMT2ATDP1 | |
| SCHEMBL8384990 | 0.70 | ALDH1A1 (0.69) | TSHRMAPTKDM4EMEN1KMT2A | |
| SCHEMBL8441847 | 0.69 | NPSR1 (0.40) | TSHRMAPTKDM4EGAANPSR1 | |
| SCHEMBL8034242 | 0.67 | HPGD (0.47) | KDM4EGAAALDH1A1NPSR1LMNA | |
| SCHEMBL8438113 | 0.67 | HPGD (0.60) | TSHRKDM4EGAAALDH1A1NPSR1 | |
| SCHEMBL8034542 | 0.67 | DHODH (0.37) | TSHRMAPTKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0758647-A1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | claimed |
| EP-0758647-B1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 2000-11-02 | — | — | EP | disclosed |
| EP-0758647-A1 | Acyl substituted aminopyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | disclosed |