Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.54 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.54 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.54 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.54 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.54 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.54 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7835578 | 0.95 | CA1 (0.63) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL7835190 | 0.93 | ENPP2 (0.62) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL7834329 | 0.93 | ENPP2 (0.62) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL10474875 | 0.93 | ENPP2 (0.62) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL27600908 | 0.93 | ENPP2 (0.62) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL7833686 | 0.89 | TP53 (0.72) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL6029015 | 0.88 | ALDH1A1 (0.60) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL13973086 | 0.84 | ALDH1A1 (0.64) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL6694936 | 0.84 | HDAC3 (0.72) | ALDH1A1CA1CA2CA12CA9 | |
| SCHEMBL5537059 | 0.84 | ALDH1A1 (0.64) | ALDH1A1CA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1159299-C | Arylalkylpyridzinones | Ĭ��ר���ɷ�����˾ | 2004-07-28 | — | — | CN | disclosed |
| CN-1066729-C | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| CN-1157288-A | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1997-08-20 | — | — | CN | disclosed |
| CN-1142493-A | Arylalkylpyridzinones | MERCK PATENT GMBH (DE) | 1997-02-12 | — | — | CN | disclosed |
| US-5389642-A | Exhibit antagonistic properties toward angiotensin(II); useful for treatment of hypertensioni, aldosteronism, cardiac insufficiency, increased intraocular pressure and disorders of the central nervous system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-14 | — | — | US | disclosed |
| EP-0602521-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0505893-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1992-09-30 | — | — | EP | disclosed |