SCHEMBL8089536

SCHEMBL8089536

CC(C)C(c1ccccc1)C(Cl)Cl

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
AOC3 Q16853 2/20 0.43
TAAR1 Q96RJ0 3/20 0.41
ADRA2A P08913 1/20 0.38
ADRA2C P18825 1/20 0.38
CYP2D6 P10635 1/20 0.38
LMNA P02545 1/20 0.38
HIF1A Q16665 1/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.37
SLC22A2 O15244 1/20 0.37
HDAC1 Q13547 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
DPP4 P27487 2/20 0.36
F2 P00734 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9239618 0.85 TSHR (0.48) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL825973 0.84 AOC3 (0.50) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL15277280 0.79 TSHR (0.42) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL3886956 0.77 AOC3 (0.45) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL17084095 0.75 ADRA2C (0.48) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL21789841 0.75 ADRA2C (0.48) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL15222220 0.75 ADRA2C (0.48) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL17084114 0.75 ADRA2C (0.48) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL8094329 0.75 AOC3 (0.43) TSHRAOC3TAAR1ADRA2AADRA2C
SCHEMBL16233141 0.75 ADRA2A (0.54) AOC3TAAR1ADRA2AADRA2CCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053990-A2 A method of producing an aromatic ketone and an aromatic ketone composition containing it TORAY INDUSTRIES, INC. (JP) 2000-11-22 EP disclosed