Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6124712 | 0.90 | MAP3K14 (0.39) | ITGB2ICAM1ITGALMAP3K14NR3C1 | |
| SCHEMBL5173976 | 0.87 | NR3C1 (0.38) | ITGB2ICAM1ITGALMAP3K14NR3C1 | |
| SCHEMBL5174599 | 0.86 | NR3C1 (0.38) | ITGB2ICAM1ITGALMAP3K14NR3C1 | |
| SCHEMBL25871757 | 0.81 | ITGB2 (0.41) | ITGB2ICAM1ITGALMAP3K14LMNA | |
| SCHEMBL5467643 | 0.80 | NR3C1 (0.41) | MAP3K14NR3C1SMN1; SMN2KMT2AKIF11 | |
| SCHEMBL5173909 | 0.79 | KMT2A (0.34) | ITGB2ICAM1ITGALMAP3K14NR3C1 | |
| SCHEMBL17295888 | 0.79 | MAP3K14 (0.63) | ITGB2ICAM1ITGALMAP3K14LMNA | |
| SCHEMBL19130581 | 0.79 | MAP3K14 (0.63) | ITGB2ICAM1ITGALMAP3K14LMNA | |
| SCHEMBL7671149 | 0.77 | ITGB2 (0.38) | ITGB2ICAM1ITGALMAP3K14LMNA | |
| SCHEMBL8089535 | 0.77 | MAP3K14 (0.47) | MAP3K14NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0740665-B1 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | ALLERGAN SALES INC (US) | 2000-12-06 | — | — | EP | disclosed |
| EP-0740665-A1 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | Allergan (US) | 1996-11-06 | — | — | EP | disclosed |
| US-5519150-A | Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates | ALLERGAN (US) | 1996-05-21 | — | — | US | disclosed |
| WO-1995019973-A2 | PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES | ALLERGAN (US) | 1995-07-27 | — | — | WO | disclosed |
| US-5420295-A | Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates | ALLERGAN, INC. (US) | 1995-05-30 | — | — | US | disclosed |