Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175512 | 0.89 | KIF11 (0.34) | NR3C1KMT2AMAP3K14ITGB2ICAM1 | |
| SCHEMBL8089568 | 0.86 | ITGB2 (0.41) | NR3C1KMT2AMAP3K14ITGB2ICAM1 | |
| SCHEMBL6124712 | 0.80 | MAP3K14 (0.39) | NR3C1KMT2AMAP3K14ITGB2ICAM1 | |
| SCHEMBL3428659 | 0.79 | KMT2A (0.36) | KMT2AITGB2ICAM1ITGALSMN1; SMN2 | |
| SCHEMBL5173687 | 0.78 | KMT2A (0.35) | KMT2AITGB2ICAM1ITGALKIF11 | |
| SCHEMBL5173976 | 0.78 | NR3C1 (0.38) | NR3C1KMT2AMAP3K14ITGB2ICAM1 | |
| SCHEMBL5474798 | 0.76 | NR3C1 (0.48) | NR3C1KMT2AMAP3K14KIF11 | |
| SCHEMBL7671149 | 0.75 | ITGB2 (0.38) | KMT2AMAP3K14ITGB2ICAM1ITGAL | |
| SCHEMBL25871757 | 0.73 | ITGB2 (0.41) | KMT2AMAP3K14ITGB2ICAM1ITGAL | |
| SCHEMBL5467643 | 0.71 | NR3C1 (0.41) | NR3C1KMT2AMAP3K14KIF11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101160305-A | Substituted chroman derivatives, method for the production and the use thereof in the form of antiphlogistics | SCHERING AG (DE) | 2008-04-09 | — | — | CN | disclosed |
| EP-1869013-A1 | SUBSTITUTED CHROMAN DERIVATIVES, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF ANTIPHLOGISTICS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2007-12-26 | — | — | EP | disclosed |
| US-20070129358-A1 | Sbstituted chroman derivatives, processes for their preparation and their use as antiinflammatory agents | SCHERING AG (DE) | 2007-06-07 | — | — | US | disclosed |
| WO-2006108711-A1 | SUBSTITUTED CHROMAN DERIVATIVES, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF ANTIPHLOGISTICS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129358-A1 | Sbstituted chroman derivatives, processes for their preparation and their use as antiinflammatory agents | TNF, CXCL8, MPO | NR3C1 83/4885KMT2A 4398/4885MAP3K14 1165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.