Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20306048 | 0.85 | NPSR1 (0.31) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL8090288 | 0.73 | SLC22A2 (0.30) | — | |
| SCHEMBL20456980 | 0.73 | HSD11B1 (0.36) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL19248214 | 0.73 | HSD11B1 (0.36) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL2716449 | 0.72 | JAK2 (0.34) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL12861222 | 0.72 | JAK2 (0.34) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL12861242 | 0.72 | JAK2 (0.34) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL727714 | 0.72 | NPSR1 (0.48) | HSD11B1SMN1; SMN2 | |
| SCHEMBL13223459 | 0.69 | HSD11B1 (0.38) | HSD11B1JAK2JAK1JAK3SCN9A | |
| SCHEMBL8089728 | 0.69 | HSD11B1 (0.33) | HSD11B1JAK2JAK1JAK3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |
| EP-0661271-A1 | AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-07-05 | — | — | EP | disclosed |