Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691667 | 0.88 | IAPP (0.47) | IAPPTAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8244985 | 0.84 | IAPP (0.50) | IAPPCYP4F2CYP4A11SMN1; SMN2ALDH1A1 | |
| SCHEMBL809020 | 0.82 | TAAR1 (0.47) | IAPPTAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29712399 | 0.82 | TAAR1 (0.47) | IAPPTAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6072736 | 0.82 | TAAR1 (0.41) | IAPPTAAR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL1964215 | 0.80 | HDAC3 (0.57) | TAAR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL29381368 | 0.80 | HDAC3 (0.57) | TAAR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL809125 | 0.79 | TAAR1 (0.44) | TAAR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6073090 | 0.79 | TAAR1 (0.44) | TAAR1CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6072610 | 0.79 | TAAR1 (0.41) | TAAR1CYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776119-B9 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-06-13 | — | — | EP | disclosed |
| EP-1776119-B1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2012-01-18 | — | — | EP | disclosed |
| US-7902224-B2 | Tetrahydro-naphthalene derivatives as glucocorticoid receptor modulators | GLAXO GROUP LIMITED (GB) | 2011-03-08 | — | — | US | disclosed |
| US-20070224130-A1 | Tetrahydro-Naphthalene Derivatives as Glucocorticoid Receptor Modulators | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | US | disclosed |
| EP-1776119-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006015870-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070224130-A1 | Tetrahydro-Naphthalene Derivatives as Glucocorticoid Receptor Modulators | NR3C1, NR3C2, MC2R | IAPP 4110/4885TAAR1 1037/4885CYP1A2 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.