Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | CCKAR | P32238 | 1/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 9/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095851 | 1.00 | ACE (0.46) | ACEMMECCKARCCKBRF10 | |
| SCHEMBL8088994 | 0.92 | CCKAR (0.45) | ACEMMECCKARCCKBRF10 | |
| SCHEMBL8089891 | 0.83 | CCKAR (0.54) | CCKARCCKBRF10F2 | |
| SCHEMBL8783591 | 0.82 | CCKBR (0.52) | ACEMMECCKARCCKBR | |
| SCHEMBL8784561 | 0.78 | NPY1R (0.59) | ACEMMECCKARCCKBRF10 | |
| SCHEMBL8784568 | 0.78 | NPY1R (0.59) | ACEMMECCKARCCKBRF10 | |
| SCHEMBL8089889 | 0.78 | NPY1R (0.59) | ACEMMECCKARCCKBRF10 | |
| SCHEMBL8089998 | 0.75 | F10 (0.44) | ACEMMEF10F2CNR2 | |
| SCHEMBL8095747 | 0.75 | F10 (0.44) | ACEMMEF10F2CNR2 | |
| SCHEMBL8095859 | 0.75 | F10 (0.44) | ACEMMEF10F2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6096885-A | EXHIBIT AGONIST ACTIVITY FOR CCK-A RECEPTORS THEREBY ENABLING THEM TO MODULATE THE HORMONES GASTRIN AND CHOLECYSTOKININ IN MAMMALS. | GLAXO WELLCOME INC. (US) | 2000-08-01 | — | — | US | claimed |
| US-6096885-A | EXHIBIT AGONIST ACTIVITY FOR CCK-A RECEPTORS THEREBY ENABLING THEM TO MODULATE THE HORMONES GASTRIN AND CHOLECYSTOKININ IN MAMMALS. | GLAXO WELLCOME INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0785944-A1 | ACYL AMINO ACETAMIDE DERIVATIVES WITH AGONIST ACTIVITY FOR CCK-A RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011940-A1 | ACYL AMINO ACETAMIDE DERIVATIVES WITH AGONIST ACTIVITY FOR CCK-A RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-04-25 | — | — | WO | disclosed |