Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PYGM | P11217 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096450 | 0.89 | KMT2A (0.53) | MTORPIK3CAPIK3CDKMT2AMEN1 | |
| SCHEMBL8111517 | 0.84 | PTPN1 (0.52) | KMT2AMEN1ALDH1A1ESR1POLB | |
| SCHEMBL3065746 | 0.82 | MTOR (0.75) | MTORPIK3CAPIK3CDPOLB | |
| SCHEMBL11925797 | 0.81 | PIK3CA (0.49) | MTORPIK3CAPIK3CDKMT2AMEN1 | |
| SCHEMBL8109642 | 0.81 | PIK3CA (0.49) | MTORPIK3CAPIK3CDKMT2AMEN1 | |
| SCHEMBL3055635 | 0.80 | PIK3CA (0.73) | MTORPIK3CAPIK3CD | |
| SCHEMBL8215041 | 0.80 | PIK3CA (0.66) | MTORPIK3CAPIK3CDKMT2AMEN1 | |
| SCHEMBL8099295 | 0.80 | CYP3A4 (0.53) | KMT2AMEN1ALDH1A1POLBMAPT | |
| SCHEMBL8093349 | 0.79 | PIK3CD (0.48) | MTORPIK3CAPIK3CDKMT2AMEN1 | |
| SCHEMBL8099372 | 0.79 | PIK3CA (0.48) | MTORPIK3CAPIK3CDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |