Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090574 | 0.89 | MTOR (0.51) | KMT2AMTORMAPTMEN1PIK3CA | |
| SCHEMBL8102170 | 0.82 | CA2 (0.49) | KMT2AMAPTMEN1PIK3CAPIK3CD | |
| SCHEMBL3059619 | 0.81 | PIK3CA (0.67) | MTORPIK3CAPIK3CDATR | |
| SCHEMBL8111517 | 0.75 | PTPN1 (0.52) | KMT2AMAPTMEN1 | |
| SCHEMBL3065746 | 0.73 | MTOR (0.75) | MTORPIK3CAPIK3CDATR | |
| SCHEMBL8213853 | 0.73 | POLB (0.48) | KMT2AMTORMAPTMEN1PIK3CA | |
| SCHEMBL6643138 | 0.73 | HDAC1 (0.66) | KMT2AHTTMAPTMEN1RXFP2 | |
| SCHEMBL8205071 | 0.72 | PIK3CA (0.54) | KMT2AMTORMAPTMEN1RXFP1 | |
| SCHEMBL8099295 | 0.71 | CYP3A4 (0.53) | KMT2AMAPTMEN1 | |
| SCHEMBL3055635 | 0.70 | PIK3CA (0.73) | MTORPIK3CAPIK3CDATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007749-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |