Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 7/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085254 | 0.86 | MAPT (0.35) | CFTRSMN1; SMN2CYP19A1RORCABCC9 | |
| SCHEMBL8090757 | 0.85 | GAA (0.34) | CFTRSMN1; SMN2CYP19A1ABCC9MAPT | |
| SCHEMBL8088718 | 0.84 | HIF1A (0.38) | SMN1; SMN2ABCC9MAPTNR3C1GAA | |
| SCHEMBL8084404 | 0.84 | ABCC9 (0.35) | SMN1; SMN2ABCC9MAPT | |
| SCHEMBL8084314 | 0.84 | RECQL (0.43) | SMN1; SMN2ABCC9MAPTGAA | |
| SCHEMBL8088939 | 0.84 | ABCC9 (0.40) | ABCC9CYP1A2 | |
| SCHEMBL8084968 | 0.84 | HTT (0.37) | SMN1; SMN2ABCC9MAPT | |
| SCHEMBL8084939 | 0.84 | ABCC9 (0.35) | ABCC9MAPTGAA | |
| SCHEMBL8088491 | 0.84 | ALDH1A1 (0.36) | SMN1; SMN2ABCC9MAPTCYP1A2GAA | |
| SCHEMBL8085157 | 0.82 | ABCC9 (0.47) | CFTRSMN1; SMN2CYP19A1RORCABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| US-5013853-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1991-05-07 | — | — | US | disclosed |
| EP-0340718-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1989-11-08 | — | — | EP | disclosed |