Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7266931 | 0.91 | RXFP1 (0.32) | RXFP1ALDH1A1HSD17B10TDP1 | |
| SCHEMBL8084378 | 0.82 | ATM (0.32) | ALDH1A1 | |
| SCHEMBL8088443 | 0.80 | MAOB (0.38) | MAOB | |
| SCHEMBL8085330 | 0.79 | F10 (0.40) | ALDH1A1HSD17B10 | |
| SCHEMBL8085208 | 0.78 | F10 (0.33) | — | |
| SCHEMBL8085042 | 0.78 | RXFP1 (0.31) | RXFP1ALDH1A1 | |
| SCHEMBL8084219 | 0.77 | KDM4E (0.36) | ALDH1A1MAOBHSD17B10 | |
| SCHEMBL9559330 | 0.76 | HRH4 (0.31) | — | |
| SCHEMBL7298021 | 0.76 | CA12 (0.40) | MAOB | |
| SCHEMBL8084230 | 0.76 | HRH4 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |
| EP-0273262-A2 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |