Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084219 | 0.85 | KDM4E (0.36) | ATMALDH1A1HPGDHRH4ADK | |
| SCHEMBL9796819 | 0.84 | HRH4 (0.34) | ALDH1A1HPGDHRH4 | |
| SCHEMBL8085076 | 0.84 | NPSR1 (0.34) | MAPTHRH4 | |
| SCHEMBL7294108 | 0.84 | CA12 (0.40) | HRH4 | |
| SCHEMBL8077246 | 0.84 | HSD11B1 (0.34) | ALDH1A1MAPTHPGD | |
| SCHEMBL8084230 | 0.84 | HRH4 (0.30) | HRH4 | |
| SCHEMBL8088499 | 0.84 | TP53 (0.34) | MAPT | |
| SCHEMBL7298021 | 0.84 | CA12 (0.40) | — | |
| SCHEMBL9587529 | 0.82 | — | — | |
| SCHEMBL8090592 | 0.82 | RXFP1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153627-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-28 | — | — | US | disclosed |
| US-6040308-A | Chroman derivatives | MERCK GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-03-21 | — | — | US | disclosed |
| US-5387587-A | Chroman derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-07 | — | — | US | disclosed |