Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.40 |
| ▸ | MTOR | P42345 | 7/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097448 | 0.93 | PIK3CA (0.43) | PIK3CAMTORPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8098293 | 0.91 | PIK3CA (0.42) | PIK3CAMTORPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8097556 | 0.91 | PIK3CA (0.42) | PIK3CAMTORPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8090759 | 0.89 | MTOR (0.41) | PIK3CAMTORPIK3CGPIP4K2APIP4K2B | |
| SCHEMBL8092043 | 0.88 | MTOR (0.49) | PIK3CAMTORPIK3CGPIK3CDATR | |
| SCHEMBL8092066 | 0.88 | PIK3CA (0.44) | PIK3CAMTORPIK3CGPIK3CD | |
| SCHEMBL8083835 | 0.86 | MTOR (0.39) | PIK3CAMTORPIK3CDATR | |
| SCHEMBL8091635 | 0.84 | ATR (0.47) | PIK3CAMTORPIK3CGPIK3CDKMT2A | |
| SCHEMBL8083616 | 0.82 | ATR (0.42) | PIK3CAMTORPIK3CDKMT2AATR | |
| SCHEMBL8089874 | 0.82 | PIK3CD (0.45) | PIK3CAMTORPIK3CGPIK3CDATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |