Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 4/20 | 0.42 |
| ▸ | KIF11 | P52732 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083011 | 0.96 | ATR (0.39) | ATRKIF11MEN1ALDH1A1MAPT | |
| SCHEMBL8103635 | 0.96 | ATR (0.39) | ATRKIF11MEN1ALDH1A1MAPT | |
| SCHEMBL8084829 | 0.90 | ATR (0.41) | ATRKIF11MEN1ALDH1A1MAPT | |
| SCHEMBL8097448 | 0.89 | PIK3CA (0.43) | ATRMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8089537 | 0.88 | KIF11 (0.40) | ATRKIF11MEN1ALDH1A1MAPT | |
| SCHEMBL8091998 | 0.88 | KIF11 (0.40) | KIF11MEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8091635 | 0.88 | ATR (0.47) | ATRMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8089874 | 0.86 | PIK3CD (0.45) | ATRPIK3CDMTORPIK3CA | |
| SCHEMBL8098188 | 0.86 | CA12 (0.44) | ATRMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8097556 | 0.85 | PIK3CA (0.42) | ATRKMT2APIK3CDMTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |