Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | MITF | O75030 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29579875 | 0.81 | KDM4E (1.00) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL18646497 | 0.81 | KDM4E (0.64) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL878950 | 0.79 | OPRK1 (0.52) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL31023227 | 0.79 | KDM4E (0.49) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL8115842 | 0.79 | KDM4E (0.49) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL1781881 | 0.78 | GAA (0.69) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL16407660 | 0.78 | MAPT (0.47) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL8098163 | 0.77 | RAB9A (0.61) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL13321137 | 0.77 | GAA (0.68) | KDM4ERAB9AGAALMNAHTT | |
| SCHEMBL17058834 | 0.77 | GAA (0.68) | KDM4ERAB9AGAALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9822078-B2 | Quinoline compounds | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-11-21 | — | — | US | disclosed |
| US-9822078-B2 | Quinoline compounds | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2017-11-21 | — | — | US | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| WO-2017044889-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
| EP-0795547-B1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AG (DE) | 2000-05-10 | — | — | EP | disclosed |
| EP-0795547-A1 | (Aminoalkyl- and acylaminoalkyl-oxy)benzyloxyquinolines, process for their preparation and use as Bradykinin receptor antagonists | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-17 | — | — | EP | disclosed |