Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083970 | 0.89 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8098808 | 0.89 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8100085 | 0.89 | NAMPT (0.38) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8090849 | 0.87 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8090846 | 0.87 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8098135 | 0.87 | MTOR (0.39) | NAMPTPIK3CDPIK3CAATR | |
| SCHEMBL8099754 | 0.86 | CHRNA7 (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8091924 | 0.85 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 | |
| SCHEMBL8090842 | 0.85 | KDR (0.38) | CA12CA1CA2CA9PIK3CA | |
| SCHEMBL8098769 | 0.84 | NAMPT (0.39) | NAMPTPIK3CDCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |