SCHEMBL8091924 — predicted protein targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	NAMPT	P43490	3/20	0.39

▸	PIK3CD	O00329	8/20	0.39

▸	KDR	P35968	1/20	0.39

▸	PIK3CA	P42336	4/20	0.37

▸	CA12	O43570	2/20	0.37

▸	CA1	P00915	2/20	0.37

▸	CA2	P00918	2/20	0.37

▸	CA9	Q16790	2/20	0.37

▸	RAB9A	P51151	1/20	0.37

▸	ATR	Q13535	1/20	0.36

▸	KIT	P10721	1/20	0.36

▸	L3MBTL1	Q9Y468	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8090849	0.89	NAMPT (0.39)	NAMPTPIK3CDPIK3CACA12CA1
SCHEMBL8090846	0.89	NAMPT (0.39)	NAMPTPIK3CDPIK3CACA12CA1
SCHEMBL8083970	0.89	NAMPT (0.39)	NAMPTPIK3CDPIK3CACA12CA1
SCHEMBL8098769	0.89	NAMPT (0.39)	NAMPTPIK3CDKDRCA12CA1
SCHEMBL8098808	0.89	NAMPT (0.39)	NAMPTPIK3CDPIK3CACA12CA1
SCHEMBL8096070	0.89	MTOR (0.40)	NAMPTPIK3CDPIK3CAATR
SCHEMBL8092385	0.88	PIK3CD (0.41)	NAMPTPIK3CDKDRPIK3CACA12
SCHEMBL8099754	0.88	CHRNA7 (0.39)	NAMPTPIK3CDKDRPIK3CACA12
SCHEMBL8097714	0.88	NAMPT (0.39)	NAMPTPIK3CDPIK3CACA12CA1
SCHEMBL8092294	0.86	ROCK2 (0.39)	NAMPTPIK3CDPIK3CACA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009007748-A2	TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES	ASTRAZENECA AB (SE)	2009-01-15	—	—	WO	disclosed