Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845195 | 0.88 | MAPT (0.44) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| SCHEMBL8050715 | 0.77 | KMT2A (0.64) | CYP4F2CYP4A11ALDH1A1GAAKDM4E | |
| SCHEMBL8099995 | 0.77 | ALDH1A1 (0.54) | CYP4F2CYP4A11ALDH1A1GAAHSD17B10 | |
| SCHEMBL3542730 | 0.74 | CYP4F2 (0.52) | CYP4F2CYP4A11PDE3BPDE3AP2RY12 | |
| SCHEMBL7845284 | 0.74 | PARP1 (0.40) | — | |
| SCHEMBL7846571 | 0.74 | PDE3B (0.38) | CYP4F2CYP4A11ALDH1A1GAAKDM4E | |
| SCHEMBL10907923 | 0.74 | NPC1 (0.48) | ALDH1A1GAAKDM4EKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL4784560 | 0.73 | CYP4F2 (0.51) | CYP4F2CYP4A11PDE3BPDE3AP2RY12 | |
| SCHEMBL7844888 | 0.72 | JAK1 (0.36) | ALDH1A1MAPTHPGDBRD4 | |
| SCHEMBL13008740 | 0.72 | CYP4F2 (0.50) | CYP4F2CYP4A11PDE3BPDE3AP2RY12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |