Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.45 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847761 | 0.86 | BRD4 (0.50) | ALDH1A1GAABRD4CYP4Z1HSD17B1 | |
| SCHEMBL6227273 | 0.80 | AKR1B1 (0.49) | HSD17B1ACACBCASP1CASP7HSD17B10 | |
| SCHEMBL22815609 | 0.78 | BRD4 (0.82) | ALDH1A1GAABRD4PDE3BPDE3A | |
| SCHEMBL8002225 | 0.78 | ACACB (0.44) | BRD4HSD17B1HRH3ACACBMAOA | |
| SCHEMBL8091023 | 0.77 | CYP4F2 (0.48) | ALDH1A1GAABRD4CYP4F2CYP4A11 | |
| SCHEMBL8766626 | 0.76 | CYP4F2 (0.50) | ALDH1A1GAABRD4CYP4F2CYP4A11 | |
| SCHEMBL13256055 | 0.76 | BRD4 (0.60) | ALDH1A1GAABRD4HRH3MAOA | |
| SCHEMBL68902 | 0.75 | CYP4F2 (0.85) | CYP4F2CYP4A11PDE3BPDE3AP2RY12 | |
| SCHEMBL3238273 | 0.75 | CASP1 (0.47) | HSD17B1HRH3ACACBMAOAMAOB | |
| SCHEMBL24229262 | 0.75 | CASP1 (0.41) | HSD17B1ACACBMAOAMAOBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |