SCHEMBL8091246

SCHEMBL8091246

Cc1ccc(CCNCCCCCc2ccccc2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 11/20 0.79
DRD3 P35462 2/20 0.60
DRD2 P14416 1/20 0.60
DRD4 P21917 1/20 0.60
ADRB2 P07550 1/20 0.58
ADORA3 P0DMS8 1/20 0.58
CHRM1 P11229 1/20 0.58
ADRA2B P18089 1/20 0.58
ADRA2C P18825 1/20 0.58
DRD1 P21728 1/20 0.58
SLC6A2 P23975 1/20 0.58
SLC6A4 P31645 1/20 0.58
ADRA1A P35348 1/20 0.58
PTGS2 P35354 1/20 0.58
HRH1 P35367 1/20 0.58
OPRK1 P41145 1/20 0.58
SLC6A3 Q01959 1/20 0.58
PDE4D Q08499 1/20 0.58
KCNH2 Q12809 1/20 0.58
HRH3 Q9Y5N1 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20689753 0.96 SIGMAR1 (0.72) SIGMAR1DRD3DRD2DRD4ADRB2
SCHEMBL9375124 0.94 SIGMAR1 (0.73) SIGMAR1
SCHEMBL9973186 0.91 SIGMAR1 (0.75) SIGMAR1DRD3DRD2DRD4
SCHEMBL8091327 0.89 SIGMAR1 (1.00) SIGMAR1
SCHEMBL7369457 0.89 SIGMAR1 (1.00) SIGMAR1
SCHEMBL8084143 0.87 SIGMAR1 (1.00) SIGMAR1
SCHEMBL8092817 0.85 SIGMAR1 (0.72) SIGMAR1DRD3ADRB2ADORA3CHRM1
SCHEMBL9819797 0.85 SIGMAR1 (1.00) SIGMAR1
SCHEMBL20689719 0.85 SIGMAR1 (0.91) SIGMAR1DRD3ADRB2ADORA3CHRM1
SCHEMBL9819849 0.85 SIGMAR1 (1.00) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US claimed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP claimed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO claimed
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed