Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190054 | 0.88 | SMN1; SMN2 (0.61) | L3MBTL1ATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9063682 | 0.88 | SMN1; SMN2 (0.61) | L3MBTL1ATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4345247 | 0.88 | SMN1; SMN2 (0.61) | L3MBTL1ATMSMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3756451 | 0.86 | SMN1; SMN2 (0.59) | L3MBTL1ATMCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL8092732 | 0.85 | SMN1; SMN2 (0.63) | L3MBTL1ATMCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11883479 | 0.84 | SMN1; SMN2 (0.56) | L3MBTL1ATMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL7176511 | 0.83 | MEN1 (0.49) | L3MBTL1CYP1A2CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL8092329 | 0.81 | TDP1 (0.59) | L3MBTL1TDP1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4459857 | 0.81 | ATM (0.55) | L3MBTL1ATMCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL28295645 | 0.81 | ATM (0.58) | L3MBTL1ATMCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |