Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4345247 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2AL3MBTL1CHRM2 | |
| SCHEMBL9063682 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2AL3MBTL1CHRM2 | |
| SCHEMBL2190054 | 0.89 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2AL3MBTL1CHRM2 | |
| Hydrochloric Acid SCHEMBL3756451 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1KMT2AL3MBTL1HTT | |
| SCHEMBL11883479 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AL3MBTL1CHRM2 | |
| SCHEMBL8091287 | 0.85 | L3MBTL1 (0.57) | SMN1; SMN2MEN1KMT2AL3MBTL1CHRM2 | |
| SCHEMBL7176511 | 0.85 | MEN1 (0.49) | SMN1; SMN2MEN1KMT2AL3MBTL1HTT | |
| SCHEMBL5272038 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2APKML3MBTL1 | |
| SCHEMBL5269597 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1KMT2APKML3MBTL1 | |
| SCHEMBL8092329 | 0.82 | TDP1 (0.59) | SMN1; SMN2MEN1KMT2AL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |