Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 9/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090252 | 0.91 | VDR (0.56) | VDR | |
| SCHEMBL25314638 | 0.91 | VDR (0.56) | VDR | |
| SCHEMBL25895008 | 0.91 | VDR (0.56) | VDR | |
| SCHEMBL25314634 | 0.91 | VDR (0.56) | VDR | |
| SCHEMBL25410119 | 0.90 | VDR (0.53) | VDRHDAC6HDAC3HDAC2 | |
| SCHEMBL25894630 | 0.90 | VDR (0.53) | VDRHDAC6HDAC3HDAC2 | |
| SCHEMBL25894696 | 0.90 | VDR (0.53) | VDRHDAC6HDAC3HDAC2 | |
| SCHEMBL25410122 | 0.90 | VDR (0.53) | VDRHDAC6HDAC3HDAC2 | |
| SCHEMBL14569115 | 0.90 | VDR (0.51) | VDRHDAC6 | |
| SCHEMBL7147391 | 0.90 | VDR (0.51) | VDRHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043385-A | TREATMENT OF PSORIASIS, BASAL CELL CARCINOMAS, DISORDERS OF KERATINIZATION AND KERATOSIS, NEOPLASTIC DISEASES SUCH AS LEUKEMIA, DISORDERS OF THE SEBACEOUS GLANDS SUCH AS ACNE AND SEBORRHOIC DERMATITIS, OSTEOPOROSIS, HYPERPARATHYROIDISM | HOFFMAN-LA ROCHE INC. (US) | 2000-03-28 | — | — | US | disclosed |