Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844219 | 1.00 | HTR1A (0.45) | HTR1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12592386 | 0.80 | HTR1A (0.36) | HTR1AALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8100761 | 0.80 | HTR1A (0.43) | HTR1AAURKACYP2D6CCR5CYP19A1 | |
| SCHEMBL7845967 | 0.80 | HTR1A (0.43) | HTR1AAURKACYP2D6CCR5CYP19A1 | |
| SCHEMBL8099072 | 0.80 | HTR1A (0.43) | HTR1AAURKACYP2D6CCR5CYP19A1 | |
| SCHEMBL7835585 | 0.80 | HTR1A (0.43) | HTR1AAURKACYP2D6CCR5CYP19A1 | |
| Hydrochloric Acid SCHEMBL7851181 | 0.79 | HTR1A (0.42) | HTR1AAURKACYP2D6CCR5CYP19A1 | |
| SCHEMBL9458462 | 0.71 | HTR1A (0.62) | HTR1A | |
| SCHEMBL9458466 | 0.71 | HTR1A (0.62) | HTR1A | |
| SCHEMBL9458475 | 0.71 | HTR1A (0.62) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046207-A | FOR INHIBITING ALPHA-1 ADRENORECEPTORS AND TREATING BENIGN PROSTATIC HYPERPLASIA, ALSO CALLED BENIGN PROSTATIC HYPERTROPHY, OR OTHER UROLOGICAL OR GYNECOLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION, NEUROGENIC BLADDER | ABBOTT LABORATORIES | 2000-04-04 | — | — | US | disclosed |
| US-5891882-A | TREATING BENIGN PROSTATIC HYPERPLASIA OR OTHER UROLOGICAL DISEASES SUCH AS BLADDER OUTLET OBSTRUCTION AND NEUROGENIC BLADDER, OR GYNECOLOGICAL SYNDROMES SUCH AS DYSMENORRHEA | ABBOTT LABORATORIES (US) | 1999-04-06 | — | — | US | disclosed |