SCHEMBL8091787

SCHEMBL8091787

O=C(c1ccc(Cl)cc1)c1ccc(CS)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.67
SRD5A2 P31213 1/20 0.57
MAPK1 P28482 1/20 0.57
VNN1 O95497 2/20 0.51
HPGD P15428 1/20 0.50
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
ALDH1A1 P00352 2/20 0.47
GSK3B P49841 2/20 0.47
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
MAPT P10636 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CNR1 P21554 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1200737 0.89 SRD5A2 (0.48) IDO1SRD5A2HPGDALDH1A1LMNA
SCHEMBL11464002 0.83 SRD5A2 (0.61) SRD5A2MAPK1VNN1HPGDCES2
SCHEMBL9065883 0.83 SRD5A2 (0.61) SRD5A2MAPK1VNN1HPGDCES2
SCHEMBL307618 0.82
SCHEMBL9065412 0.82 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL51827 0.82 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL10697158 0.82 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL1681512 0.82 SRD5A2 (0.80) SRD5A2MAPK1HPGDCES2CES1
SCHEMBL7015674 0.81 SRD5A2 (0.59) SRD5A2MAPK1VNN1HPGDCES2
SCHEMBL15025047 0.81 SRD5A2 (0.41) IDO1SRD5A2HPGDALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058682-A1 HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS LABORATOIRES UPSA (FR) 2000-12-13 EP disclosed
US-6004994-A ANTIINFLAMMATORY AGENTS, CYCLOOXYGENASE INHIBITORS AND ANALGESICS LABORATOIRES UPSA (FR) 1999-12-21 US disclosed
WO-1999043664-A1 HETEROCYCLIC DIARYLMETHYLENE DERIVATIVES, METHODS OF PREPARING THEM AND THEIR USES IN THERAPEUTICS LABORATOIRES UPSA (FR) 1999-09-02 WO disclosed
EP-0766666-B1 BENZYLSULFIDE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO (JP) 1999-03-17 EP disclosed
US-5728699-A Benzylsulfide derivative, process for its production and pesticide KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1998-03-17 US disclosed
EP-0766666-A1 BENZYLSULFIDE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1997-04-09 EP disclosed
WO-1996033168-A1 BENZYLSULFIDE DERIVATIVE, PROCESS FOR ITS PRODUCTION AND PESTICIDE KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1996-10-24 WO disclosed