Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.91 |
| ▸ | DRD3 | P35462 | 11/20 | 0.91 |
| ▸ | HTR1A | P08908 | 4/20 | 0.72 |
| ▸ | HTR7 | P34969 | 3/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8086599 | 0.95 | DRD3 (1.00) | DRD2DRD3HTR1AHTR7HRH3 | |
| SCHEMBL8086583 | 0.94 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7HRH3 | |
| SCHEMBL8091832 | 0.87 | DRD2 (0.70) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8085463 | 0.84 | DRD2 (0.67) | DRD2DRD3HTR1AHTR7DRD4 | |
| Hydrochloric Acid SCHEMBL8091842 | 0.84 | DRD2 (0.66) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8078634 | 0.83 | DRD2 (0.77) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8091851 | 0.82 | DRD2 (0.78) | DRD2DRD3HTR1AHTR7DRD4 | |
| SCHEMBL8086604 | 0.81 | DRD2 (0.61) | DRD2DRD3HRH3ADRA1AALDH1A1 | |
| SCHEMBL8085595 | 0.80 | DRD2 (0.73) | DRD2DRD3HTR1AHTR7DRD4 | |
| Hydrochloric Acid SCHEMBL8078633 | 0.80 | DRD2 (0.61) | DRD2DRD3HRH3ADRA1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103724-A | EXHIBIT MAINLY ANTIPSYCHOTIC EFFECTS, E.G., SCHIZOPHRENIA, ORGANIC MENTAL DISORDERS, AFFECTIVE DISORDERS, ANXIETY, PERSONALITY DISORDERS; NEUROLEPTIC ACTIVITIY; ATYPICAL ANTIPSYCHOTICS, COGNITION ACTIVATORS, ANTIDEPRESSANTS; | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2000-08-15 | — | — | US | disclosed |